Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function

J Med Chem. 2000 Apr 6;43(7):1251-2. doi: 10.1021/jm990583r.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Line
  • Dynorphins / metabolism
  • Dynorphins / pharmacology*
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology*
  • Point Mutation
  • Polymerase Chain Reaction
  • Radioligand Assay
  • Receptors, Opioid, kappa / agonists*
  • Receptors, Opioid, kappa / genetics
  • Receptors, Opioid, kappa / metabolism
  • Structure-Activity Relationship

Substances

  • Peptide Fragments
  • Receptors, Opioid, kappa
  • dynorphin (1-13)
  • Dynorphins